- Celal Bayar Üniversitesi Fen Bilimleri Dergisi
- Vol: 17 Issue: 1
- Newly Axial Silicon(IV) Phthalocyanine Photosensitizer: Design, Synthesis and Photochemical Properti...
Newly Axial Silicon(IV) Phthalocyanine Photosensitizer: Design, Synthesis and Photochemical Properties
Authors : Gülçin Ekineker, Hülya Yanik
Pages : 11-16
Doi:10.18466/cbayarfbe.821910
View : 18 | Download : 8
Publication Date : 2020-12-30
Article Type : Research
Abstract :Used as photosensitizer in photodynamic therapy, phthalocyanines exhibit their long wavelength absorption and the ability to produce high singlet oxygen for tumor destruction with 650 to 800 nm fluorescence.Phthalocyanines with their long wavelength absorption and fluorescence from 650 to 800 nm exhibit their ability to produce high singlet oxygen for the destruction of tumors. In this study, new axial substituted silicon(IV) phthalocyanine (4) was synthesized. Unsubstituted dichlorosilicon phthalocyanine was synthesized from 1,3-diiminoisoindoline via cyclotetramerization. The axial substitution reaction was carried out using dichlorosilicon(IV) phthalocyanine and excess of 2-methoxyethanol. Structural characterization of this new axial-substituted silicon(IV) phthalocyanine by IR, mass, and UV-Vis spectroscopy were performed. Photochemical properties were investigated for cancer therapy. In this study, we found that axial substituted silicon(IV) phthalocyanine (4) may be promising PDT agent.Keywords : Axial, , silicon(IV) phthalocyanine, , photosensitizer, , Photodynamic Therapy,