- Beden Eğitimi ve Spor Bilimleri Dergisi
- Vol: 4 Issue: 1
- DENEYSEL ARTRİT MODELİNDE İNTRAARTİKOLER HYALURONIK ASİT VE METİL PREDNİSOLON ASETATIN KIKIRDAK OZER...
DENEYSEL ARTRİT MODELİNDE İNTRAARTİKOLER HYALURONIK ASİT VE METİL PREDNİSOLON ASETATIN KIKIRDAK OZERİNE ETKİLERİ / EFFECTS OF INTRAARTICULAR HYALURONIC ACID AND METHYL PREDNISOLONE ACETATE ON CARTILAGE IN A MODEL OF EXPERIMENTAL ARTHRITIS
Authors : Şirzat Çoğalgil, Orhan Karsan, Lale Cerrahoğlu, Halis Süleyman, Cemal Gündoğdu, Fazlı Erdoğan
Pages : 0-0
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Publication Date : 2010-02-20
Article Type : Other
Abstract :Dejeneratil artritlerde intraartikuler olarak uygulanan hyaluronik asit (HA) ve metil prednisolon asetat (MPA) tedavilerinin etkilerini ara$tlrmak i9in deneysel bir 9all!~ma yaplldl. 40 adet erkek raM sag arka diz eklemleri i9ine 0.2 ml %1'lik lormalin veriierek deneysel artrit olu$turuldu. IIa9 verilmesinden bir hafta sonra 10 rat 61dunJlerek artrilin olu$tugu histopatolojik olarak be/iriendi. Kalan 30 rat 3 gruba aynldl. Birinci gruba 0.05 ml intraartikiiler HA (HA grubu), ikinci gruba 0.05 ml intraartikLiler MPA (MPA grubu) verildi. 09uncu gruba ise intraartikiiler 0.05 ml serum lizyolojik venlerek kontrol grubu olu$turuldu. Tedaviler artrit olu$turulduktan sonra 7. Gun, 14. Gun ve 21. gun uygulandl. Uygulanan bu tedavilerin bitiminden 15 giin sonra rat/ar 61duriildu ve alman omekler, histopatolojik olarak incelendi. Yapilan incelemede; MPA grubunda klkmjak iyile$mesi a9lsmdan kontrol grubuna g6re anlaml! fark bulunamadl (p>0.05). HA grubunda ise klklrdak iyile$mesi MPA ve kontrol grubuna gore anlamli olarak yiiksek bulundu (p<0.05). Intraartikiiler artrit tedavisinde klklrdak dokusu uzerine olumlu etkilerinden dolaYI HA'in MPA 'a g6re daha yararll oldugu sonucuna vanldl. Anahtar kelimeler: Oeneysel artrit, klklrdak, hyaluronik asit, metil prednisolon asetat. SUMMARY This experimental study was performed to determine the effects of intraarticular hyaluronic acid (HA) and methyl prednisolone acetate (MPA) in degenerative osteoarthritis. 0.2 ml 1% formaline were injected to the posterior right knee joints of 40 male rats. One week after the injections. 10 rats were killed and arthritis was determined histopathologically. The remained 30 rats were divided to three groups. First group received intraarticularly 0.05 ml HA (HA group), second group 005 ml MPA (MPA group) and third group 0.05 ml saline as controls. The injections were performed at 7., 14. and 21- days after the arthritis. 15 days after the end of these treatments, rats were killed and sections were examined histopathologically. There was no significantly difference in cartilage healing between MPA and control groups (p>0.05). However cartilage healing was significantly high in HA group compared to MPA and control groups (p<0.05). It was concluded that HA is more useful than MPA in the treatment of arthritis intraarticularfy because of its positive effects on cartilage tissue. Key words: Experimental arthritis, cartilage, hyaluronic acid, methyl prednisolone acetate.Keywords :