- Journal of the Turkish Chemical Society Section A: Chemistry
- Vol: 3 Issue: 3 Special Issue
- SYNTHESIS OF NOVEL FLUOROQUINOLONE-TRIAZOLE HYBRID COMPOUNDS AS ANTIMICROBIAL AGENTS
SYNTHESIS OF NOVEL FLUOROQUINOLONE-TRIAZOLE HYBRID COMPOUNDS AS ANTIMICROBIAL AGENTS
Authors : Serap Başoğlu Özdemir
Pages : 515-534
Doi:10.18596/jotcsa.55734
View : 5 | Download : 5
Publication Date : 2017-01-08
Article Type : Other
Abstract :Abstract: The hydrazide compound ( 2 ) was synthesized starting from 1-(2-fluorophenyl)piperazine via two stage. The reaction of compound ( 2 ) with different alkyl(aryl)isothiocyanates afforded the corresponding compounds ( 3a-c ) . 1,3-Thiazolidine derivatives ( 4a-c ) were synthesized from the treatment of ( 3a-c ) with ethyl bromoacetate. Mannich bases ( 6a-d ) were yielded the treayment of ( 5a-c) with various suitable amines in the exictence of formaldehyde. Compound ( 3 ) derivatives were converted to 1,2,4-triazole as the starting material of fluoroquinolone analogues ( 11a-c ). Finally synthesized compounds were examined their biological properties and some of these showed potent activity.Keywords :