- Journal of Contemporary Medicine
- Cilt: 13 Sayı: 6
- ADAMANTINOMA-LIKE EWING SARCOMA OF THE PAROTID WITH EWSR1-FLI1 REARRANGEMENT: A CASE REPORT AND REVI...
ADAMANTINOMA-LIKE EWING SARCOMA OF THE PAROTID WITH EWSR1-FLI1 REARRANGEMENT: A CASE REPORT AND REVIEW OF THE LITERATURE
Authors : Serdar Uğraş, Zeliha Esin Çelik
Pages : 1131-1133
View : 53 | Download : 87
Publication Date : 2023-11-30
Article Type : Other
Abstract :Adamantinoma-like Ewing sarcoma (ALES) is a rare tumor that shows epithelial differentiation in addition to EWSR1-FLI1 rearrangement. We describe a case of ALES detected as a parotid mass in a 20-year-old woman. This is the thirteenth case of ALES arising in parotid gland. Histopathologically, the tumor consisted of diffuse pattern and solid sheets of basaloid cells with oval, round nuclei, coarse chromatin and scant cytoplasm. Immunohistochemically, tumor cells were positive with CD99, NKX2.2, p40, pancytokeratin and synaptophysin. Additionally, ESWR1-FLI1 rearrangement was demonstrated with FISH. The diagnosis of ALES may be very challenging due to the potential mimics. The precise diagnosis of ALES depends on both morphologic and immunohistochemical findings and has to be supported by molecular analysis determining EWSR1-FLI1 rearrangement.Keywords : Adamantinoma benzeri, Ewing sarkomu, ESWR1-FLI1 rearanjmanı, , parotis