- Hacettepe Journal of Biology and Chemistry
- Issue: 4
- The Isolation of L-Asparaginase and L-Serine Dehydratase from Bacteria
The Isolation of L-Asparaginase and L-Serine Dehydratase from Bacteria
Authors : Nazif Kolankaya, Atilla Atalay, Sevda Gokdeniz
Pages : 17-23
View : 9 | Download : 3
Publication Date : 1975-05-01
Article Type : Other
Abstract :Kidd 1953 first observed that certain transplanted lymphomas of mice and rats were strongly suppressed by treatment with guinea pig serum, and Broome 1961 provided evidence that L-asparaginase in the serum is the antitumoral factor. The finding by Mashburn and Wriston 1964 that L-asparaginase derived from Escherichia coli has antitumor activity similar to that of guinea pig serum opened up the possibility of large scale production of the enzyme for ultimate clinical trial.Keywords :