Effects of Bromelain on Oxidative Stress and Lung Tissue Histopathology in an Experimental Rat Sepsis Model

Authors : Nurhan Akaras, Erdem Toktay, Hasan Şimşek, Nevra Aydemir Celep, Neslihan Yüce

Pages : 252-259

Doi:10.30607/kvj.1302701

View : 209 | Download : 221

Publication Date : 2023-09-30

Article Type : Research

Abstract :Sepsis is an inflammatory syndrome that targets the lung tissue. Bromelain (BRO) is an enzyme complex known for its anti-inflammatory properties. In this study, the protective effect of BRO on lung injury due to sepsis induced by cecal ligation and puncture (CLP) in Sprague-Dawley rats was investigated by biochemical and histopathological methods. Forty Sprague dawley rats were randomly divided into five groups as control, CLP, BRO, CLP+BRO 50 and CLP+BRO 100. In the study, after oral administration of 50 and 100 mg/kg BRO (total of 7 applications for 7 days) to rats, laparotomy and CLP were performed. The data showed that due to its antioxidant properties, BRO decreased CLP-induced myeloperoxidase (MPO) and lipid peroxidation (MDA) (p <0,001), increased glutathione (GSH) levels, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities (p <0,001). Additionally, CLP-induced lung histological changes were reduced with BRO supplementation. The results showed that BRO treatment has an antioxidant, anti-inflammatory effect on CLP-induced lung toxicity and helps preserve lung tissue architecture owing to its regulatory effect.
Keywords : Akciğer, Bromelain, Sepsis, İnflamasyon, Oksidatif Stres