Antioxidative capacities of some GABAA receptor modulating food plants

Authors : Sümeyye Şahin

Pages : 237-242

Doi:10.29278/azd.602839

View : 21 | Download : 12

Publication Date : 2019-12-20

Article Type : Research

Abstract :Reactive oxygen species cause oxidative stress associated with some health issues such as neurodegenerative diseases. Some antioxidants show neuroprotective activity and regulate neuronal activity through positive modulation of GABA A receptors. In this study, the antioxidative capacity of some novel GABA A receptor modulating food plants, including lavender, clove and four Sideritis species ( S. arguta , S. sipylea , S. condensata , and S. stricta) was investigated using ABTS assay. The aqueous clove extract showed the most potent antioxidant effect and its IC 50 value was found to be 3.76 μg/mL. The antioxidant capacity of Trolox was lower (IC 50 : 4.63 μg/mL) than that of the clove extract, but higher than those of the other food extracts. The aqueous lavender extract exhibited less antioxidant activity compared to Sideritis species, except S. sipylea that had the least antioxidant capacity (IC 50 : 20.75 μg/mL). In conclusion, these results confirm that GABA A receptor modulating food plants possess strong antioxidative activity.
Keywords : Sideritis, Lavanta, Karanfil