THE EFFECT OF DELIVERY MODE ON NT-PROBNP LEVELS IN NEWBORNS

Authors : Ilknur Kaba, Didem Aliefendioğlu

Pages : 48-55

Doi:10.24938/kutfd.1142172

View : 15 | Download : 8

Publication Date : 2023-04-30

Article Type : Research

Abstract :Objective: Reference values of NT-proBNP levels in newborns may vary depending on gestational age, postnatal age and Apgar scores. However, the effect of the mode of delivery has been less investigated, and the results are contradictory. In this study, it was aimed to compare NT-proBNP levels in healthy term newborns born through vaginal delivery and cesarean (C/S) and to investigate whether delivery method had an effect on it. Material and Methods: Healthy newborns born in our hospital and with a gestational age of ≥38 weeks were included in the study. Cases (n=56) were grouped according to delivery type. Both groups were similar in terms of gender, gestational age, body weight and Apgar scores. NT-proBNP levels, hematological parameters, LDH and CPK levels were studied in blood samples taken in the first hours after birth. The two groups were compared in terms of these parameters and it was investigated whether there was a relationship between the parameters. Results: NT-proBNP levels were 3145 (372-7231) pg/ml in newborns born vaginally and 783 (401-6563) pg/ml in newborns born by cesarean section (p<0.05). CPK, LDH levels and white blood cell counts were higher in newborns born by vaginal delivery compared to newborns born by cesarean section (p<0.05). In addition, a positive correlation was found between NT-proBNP values and white blood cell counts (r =0.6, p=0.000). Conclusion: NT-proBNP levels of those born vaginally are in the range of predefined reference levels and increased 4 times compared to those born through C/S. In addition, the relationship between NT-proBNP levels and biochemical markers and white blood cell counts suggests that vaginal delivery causes physiological stress and this may be related to postpartum adaptation.
Keywords : NT-proBNP, yenidoğan, doğum şekli