Pages 42-47 Investigation of Pneumocystis Jiroveci Carriage in Patients with Various Lung Diseases

Authors : , Sedat Kaygusuz, Arzu Ertürk, Dilek Kiliç, Özcan Konur, Ayhan Kubar

Pages : 42-47

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Publication Date : 2008-03-01

Article Type : Other

Abstract :Pneumocyctis jiroveci is one of the major reasons of morbidity especially in immunosuppressive individuals. Recently, a large number of asymptomatic colonization has been noted. The aim is to investigate the frequency of P. jiroveci colonization in patients (Group I) with lung cancer who do not take oral corticosteroid and the patients (Group II) with other lung problems by using immunofluorescence (IF) method and polymerase chain reaction. Incidence of P. jiroveci has been investigated in the bronchoalveolar lavage samples taken by bronchoscopy for diagnose and treatment by using IF method and P. jiroveci DNA has been defined with PCR method. In Group I, 1 (1.8%) IF and 3 (5.5%) PCR positivism (one of them is the case which is found positive by using IF method) have been acquired. In Group II, both of the methods have produced no positivism. Colonization of P. jiroveci is noted in patients with HIV negative. The fact that the cases only with lung cancer have positivity supports the idea that lung cancer is important risk factor. The patients with lung cancer should be monitored closely for prophylaxis and treatment and the treatment should not be applied to each PCR positive case.
Keywords : Pneumocyctis jiroveci, PCR, immunofluorescence, lung carcinoma