Role of soluble fractalkine, GFAP and CD163 in cognitive functions after open heart surgery in diabetic and non-diabetic patients

Authors : Arif Ozbay, Sureyya Barun, Aybeniz Civan Kahve, Abdullah Özer, Özlem Gülbahar, Hasan Dağli, Seçil Özkan, Dilek Erer

Pages : 565-573

Doi:10.31067/acusaglik.1124251

View : 29 | Download : 7

Publication Date : 2022-10-01

Article Type : Research

Abstract :Purpose: In this study, the relationship between postoperative cognitive functions and serum fractalkine, Glial Fibrillar Acidic Protein (GFAP) and Cluster of differentiation 163 (CD163) levels in diabetic and non-diabetic patients after open heart surgery was evaluated. Methods and Materials: This research was planned prospectively as observational clinical study. Cognitive functions, fractalkine, GFAP and CD163 levels were evaluated with preoperative day 1 and postoperative day 7 in 44 patients. Minimental test (MM) was used to evaluate cognitive functions. Results: A positive correlation was found between preoperative CD163 concentrations and postoperative MM test scores in non-diabetic patients (r=0.536, p=0.010). There was also a positive correlation between postoperative CD163 concentrations and postoperative MM Test scores in non-diabetics (r=0.461, p=0.031). In diabetic patients, a positive correlation was found between preoperative and postoperative GFAP concentrations (r=0.792, p<0.001). Conclusion: The underlying mechanisms of Postoperative cognitive dysfunction (POCD) are thought to be different in non-diabetic and diabetic patients. Evidence suggesting that preoperative serum CD163 levels may be a candidate for biomarkers directly related to postoperative cognitive performance in non-diabetic patients. In order to prevent POCD, which is associated with mortality, it is important to determine the predictors before surgery and to select the surgical method and anesthetics according to the risk assessment.
Keywords : cognitive functions, inflammation, CD163, fractalkine, GFAP, heart surgery