Relationship Between the Serum Levels of Procalcitonin, Lactate, HgA1c and Functional Outcome in Acute Ischemic Stroke Patients

Authors : Zuhal Kalyon Karaman, Çiğdem Özpolat, Özge Onur, Haldun Akoğlu, Arzu Denizbaşi

Pages : 585-590

Doi:10.31067/acusaglik.849083

View : 48 | Download : 9

Publication Date : 2021-07-01

Article Type : Research

Abstract :Purpose:Prognostic parameters in stroke management are important for emergency department physicians to reduce mortality and morbidity. No parameters could be determined for prognosis in acute stroke. In this study, we aimed to determine whether serum procalcitonin(PCT), lactate and HgA1c levels at admission and changes of PCT and lactate levels in 2 hours were associated with short-term functional outcome (3rd day) after acute ischemic stroke. Patients and Methods:This was a prospective observational prognostic test study. All consecutive patients admitted to the emergency department and diagnosed as the first episode of acute ischemic stroke were included in the study. On admission and 2nd hour, PCT and lactate levels and admission HgA1c levels were collected from all subjects. We aimed to correlate these values with Modified Rankin Scale (mRs) and mortality on the 3rd day and to determine their predictive value. Results:There was no statistically significant difference in PCT and lactate values and in terms of PCT and lactate clearances between the favorable (mRS <2) and nonfavorable groups. There was a statistically significant difference between two groups in terms of HgA1c value. When the threshold value analysis was performed to determine the non-favorable outcome, the threshold value was determined as 5.7. Conclusion:Our results demonstrate that ischemic stroke patients with higher levels of HgA1c at the time of initial presentation have an increased risk for poor functional neurological outcome at the 3rd day.
Keywords : procalcitonin, lactate, HgA1c, stroke