Ratlarda Trinitrobenzensulfonik Asit ile Oluşturulan Deneysel Kolitte Kısa Zincirli Yağ Asitlerinin Epitel Onarımına Etkisi

Authors : Müjdat Kara, H. Ahmet Tezel

Pages : 664-670

View : 30 | Download : 11

Publication Date : 2020-12-01

Article Type : Research

Abstract :Objectives: The purpose of this study is to discuss short-chain fatty acids’ SCFA role in ulcerative colitis UC treatment by using rats which have experimental colitis created with trinitrobenzenesulfonic acid TNBS . Method: In this study, the experimental research method was adopted. The study group consisted of 30 female Wistar rats which have 150±30 gr. average weights, Rats were randomly divided into 3 groups with 10 rats in each group. The groups were randomly assigned as two experimental groups and one control group. The first experimental group was administered SCFA intracolonically 2 times a day from the 3rd day, and the second experimental group was administered SCFA 2 times a day from the first day. The control group was given saline 2 times a day from the 3rd day. On day 6, the rats were decapitated. MPO activity evaluation and macroscopic and microscopic evaluation of the colon mucosa was done. Results: There was a statistically significant difference between the colon macroscopy results of the groups 1-2, 2-3, 1-3 p
Keywords : Short-chain fatty acids. ulcerative colitis, trinitrobenzenesulfonic acid