Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü ve Hastalıkların Patogenezine Etkisi

Authors : Ayşe Tülay Aydinoğlu, Evrim Aksu Mengeş, Burcu Balcı Hayta

Pages : 372-379

View : 41 | Download : 13

Publication Date : 2020-09-01

Article Type : Other

Abstract :Mitochondria are multi-functional organelles with many essential roles in the maintenance of cell viability as well as ATP production by oxidative phosphorylation. One of the most important features of this organelle that contributes to cell viability is its own genetic system. Mitochondrial DNA mtDNA , which is located in the mitochondrial matrix under normal physiological conditions, is released into the extracellular matrix and enters the systemic circulation in case of an organelle and/or a cellular damage. Recent studies have focused on the role of mtDNA in circulation and its association with diseases. Circulating cell-free mtDNA ccf-mtDNA is regarded as a Damage Associated Molecular Pattern DAMP and recognised by the Pattern Recognition Receptors PRRs . They play a fundamental role in initiating the pro-inflammatory response. In this review, the mechanisms of ccf-mtDNA-induced inflammatory pathways in systemic circulation and the effect of ccf-mtDNA on diseases pathogenesis will be discussed
Keywords : ccf-mtDNA, systemic circulation, inflammation