Kemoterapi İlişkili Akut Solunum Yetmezliği: Relaps Langerhans Hücreli Histiositozlu Bir Çocuk

Authors : Hadi Geylan, Kamuran Karaman, Mecnun Çetin, Akkız Şahin Yaşar

Pages : 350-353

View : 33 | Download : 10

Publication Date : 2020-06-01

Article Type : Other

Abstract :Langerhans cell histiocytosis LHH ; is a clonal neoplastic proliferation of Langerhans-type cells with expressing CD1a, langerin and S100 protein and presence of Birbeck granules in the ultrastructural examination. Clinical manifestations are very variable. The bone, bone marrow, skin, lymph nodes, lung, liver, spleen and meninges are most involved. Most cases are diagnosed during childhood and the annual incidence is approximately 5 million. The agent should be selected with the least side effect according to the number of lesions and the area of invasion. Most patients respond to initial treatment. In the last 3.5 years, with the diagnosis of LHH, approximately two years after the end of chemotherapy, the patient referred to our hospital with a central diabetes insipidus. Relapse Langerhans cell histiocytosis was diagnosed as a result of imaging studies. Chemotherapy protocol with cladribine and cytarabine was started for the patient. After the third session/round/cycle of the treatment, pneumonia accompanied by rapid onset of respiratory distress developed after the febrile neutropenia recovered. Here we present a case of sudden respiratory insufficiency after cladribine and/or cytarabine chemotherapy and a dramatic response to steroid treatment
Keywords : Chemotherapy, Langerhans cell histiocytosis LHH, pneumonia