Ailevi Akdeniz Ateşi Olan Çocuklarda Ortalama Trombosit Hacminin Klinik Önemi

Authors : Dilek Doğruel, Rabia Miray Kışla Ekinci, Sibel Balci, Mustafa Yilmaz, Derya Ufuk Altintaş

Pages : 589-592

View : 60 | Download : 11

Publication Date : 2019-12-01

Article Type : Research

Abstract :Objectives: Familial Mediterranean Fever FMF is an autosomal recessive inflammatory disease characterised by recurrent involvement of serous membranes. It has been shown that the mean platelet volume MPV could be used as a marker in many inflammatory diseases. In this study, we investigated the genetic mutation in children with FMF and changes in MPV in attack and attack-free periods. Patients and Methods: The study included 110 children diagnosed with FMF based on the Tel-Hashomer Criteria. Demographic features, results of genetic analyses, complete blood count parameters, MPV levels, erythrocyte sedimentation rate ESR , C-reactive protein CRP results were evaluated retrospectively. Data of the patients were recorded separately based on the acute attack and attack-free periods under treatment. Results: The mean platelet volume was found to be 8,55±1,51 fL in the attack period and 9,61±1,18 fL in the attack-free period. The mean platelet volume was significantly lower in patients with an attack period compared to the patients at an attack-free period p=0.000 . The platelet and leukocyte count, ESR, CRP were statistically significantly higher in the attack period compared to the attack-free period p=0.000 . Conclusion: The mean platelet volume is decreased in patients with attack period and it may be a useful parameter in determining timing the attack. It is important that clinicians use this parameter when evaluating the hemogram result
Keywords : Familial Mediterranean Fever, Inflammation, Mean Platelet Volume