Nefrotoksik Kemoterapiye İkincil Böbrek Yetmezliği Gelişen Bir Olguda FDG PET/BT’de Böbrek Bulguları

Authors : Gonca Kara Gedik, Taylan Kara, Pelin Özcan Kara, Oktay Sari

Pages : 221-223

View : 42 | Download : 11

Publication Date : 2011-12-01

Article Type : Other

Abstract :A 60 year old male, diagnosed with small cell lung carcinoma was referred for FDG PET/CT for re-staging to our department. On contrast enhanced computed tomography, the diagnosis was vena cava superior syndrome due to the mass effect of small cell lung carcinoma. On FDG PET/CT imaging, a mass located at right upper lobe with increased FDG uptake, multiple increased metabolic activity foci at several locations in bone, enlargement of both renal size and diffuse increased FDG uptake at both kidneys were seen. Upon questioning the patinet explained he was treated with 450mg/m2 carboplatin 3 weeks ago. At the time of FDG PET/CT scanning, his BUN and creatinin level were 81 mg/dl n: 17-43mg/dl and 1.78mg/dl n: 0.71.2mg/dl , respectively. His urine volume was 350 cc /day during the examination. During follow-up BUN and creatinin level decreased to 48mg/dl and 1.1mg/dl and the volume of the urine was increased to normal level. It was assumed that increased FDG involvement of kidney was caused by acute tubular necrosis due to carboplatin toxicity. Normalization of renal functions and creatinin, BUN and urine volume during follow-up also supportted this thesis. Here, we present FDG PET/CT findings of a case with small cell lung carcinoma and nefrotoxicity due to carboplatin treatment
Keywords : carboplatin, nephrotoxicity, FDG PET/CT, vena cava superior syndrome