Immunolocalization of MMP-2 and MMP-9 in Placenta of Humans with Gestational Diabetes Mellitus

Authors : Elif Unsal, Yusuf Nergiz, Ercan Ayaz, Murat Akkus, Mehmet Sıddık Evsen

Pages : 12-19

View : 16 | Download : 7

Publication Date : 2016-06-15

Article Type : Research

Abstract :Background: The aim of this study was to compare of term placentas, which has gestational diabetes mellitus and normal pregnant women in terms of immunolocalization of MMP-2 and MMP-9. Methods: Fifteen gestational diabetes mellitus patients and fifteen women without any systemic disease of the placenta were collected. Fetal and maternal faces of the placentas, as well as peripheral and central parts were examined for immunohistochemical investigation of MMP-2 and MMP-9.Groups were evaluated through use of the SPSS 15.0 package program. P values ≤0.05 were considered statistically significant. Results: MMP-2 reaction was weakly expressed in maternal and fetal surface, and no significant difference between the two groups was observed. When MMP-9 expression was compared between the groups, an increase in decidual cells of diabetic group and a decrease in syncytial nodes were noticed. In fetal surface, a decrease in expression level was detected in chorionic villus syncytiotrophoblasts, chorionic villus stroma, stem villus syncytiotrophoblasts, stem villous stroma and chorionic plate. Conclusion: Regarding our findings, MMP-9 plays a more active role than MMP-2 in gestational diabetic placentas was concluded.
Keywords : Full-term human placenta, gestational diabetes mellitus, MMP-2