The Association Between Type 2 Diabetes Mellitus and Stroke, Coronary Artery Disease and Thromboembolism

Authors : Hasan M. Durgun, Cafer Guloglu, Mustafa Aldemir, Alpaslan K. Tuzcu, Mehmet Ustundag

Pages : 1-14

View : 17 | Download : 8

Publication Date : 2015-06-01

Article Type : Research

Abstract :Background: The incidence of cerebrovascular disease in diabetic patients is 6 times higher than nondiabetic patients. Approximately 85% of these patients die because of the cardiovascular diseases. DM is an independent risk factor for cardiovascular diseases, and this risk increased much with accompanying dyslipidemia. In diabetic patients, increased triglyceride and decreased HDL cholesterol accelerate atherosclerosis. In stroke patients, increased plasma Pro-BNP levels are associated directly with stroke severity and mortality. Method: Following the approval of Dicle University Medical Faculty Ethics Committee, the randomly selected patients admitted to the emergency department with the following thromboembolic complaints were investigated prospectively for 6 months study period. The patients were classified into 4 groups. Group 1: type 2 Diabetes Mellitus (DM) without thromboembolic complications; group 2: type 2 DM with thromboembolic complications; group 3: thromboembolism without DM; group 4: healthy volunteers. The coagulation factors, lipid profiles and pro-BNP levels were measured in all patients. Results: Systolic tension arterial (STA) and diastolic tension arterial (DTA) levels were significantly higher in group 2 as compared to group 1 and control groups (p < 0,05). Among groups, there were statistically significant differences in glucose, urea, creatinine, fibrinogen, factor 7, factor 8, pro-BNP, triglyceride, HDL, VLDL levels (p < 0,05). Conclusion: DM is a factor that increases STA and DTA levels. In type 2 diabetes, fibrinogen and coagulation factors such as factor 7 and factor 8 increase, anticoagulant factors decrease, HDL cholesterol levels decrease, triglyceride levels and VLDL cholesterol levels increase and pro-BNP levels increase. As a result, the risk of arteriosclerosis and thromboembolism associated with ischemic stroke, peripheral and coronary artery disease and mortality increase
Keywords : Type 2 diabetes mellitus, stroke, coronary artery disease, thromboembolism