Voltammetric analysis of class II antiarrhythmic drugs propranolol and acebutolol

Authors : Dilek Kul, Fatma Ağin

Pages : 47-54

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Publication Date : 2020-06-23

Article Type : Other

Abstract :Antiarrhythmic agents are used to suppress abnormal rhythms of the heart. Class II antiarrhythmic agents are beta blockers used to treat supraventricular tachycardias. Voltammetric analysis of class II antiarrhythmic drug active ingredients propranolol and acebutolol carried out with various modified/non-modified electrodes using cyclic voltammetry, linear sweep voltammetry, differential pulse voltammetry and square wave voltammetry were compiled from the literature. The effect of buffer solution and pH was investigated. Scan rate results obtained with the voltammetric methods showed whether the redox process of the drug active ingredient diffusion or adsorption controlled on the electrode used in the selected supporting electrolyte. Results of the quantitative analysis of these drugs were evaluated in terms of parameters such as linearity range, limit of detection, stability, robustness, repeatability, reproducibility and sensitivity. Accuracy and precision of the validated methods were investigated by combining the results obtained from the pharmaceutical dosage forms of the drug active ingredients. Finally, voltammetric behavior of the drugs in real samples such as human serum and urine was evaluated and it was examined whether the analysis results were affected by the other substances in real samples.
Keywords : Beta blockers, Acebutolol, Propranolol, Antiarrhythmic drug, voltammetry, modified electrode