The effects of Juniperus communis (Cupressaceae) oil application on the serum paraoxonase and pancreatic enzymes activities and lipid levels in experimental diabetic rats

Authors : Evan Abdulkarim Mahmood, Tahir Kahraman

Pages : 13-20

View : 27 | Download : 7

Publication Date : 2019-04-30

Article Type : Research

Abstract :Objective: Juniperus communis (JC) oil, which is among the medicinal plants, has many pharmacological activities. In this study, effects of JC oil on serum paraoxonase and pancreatic enzymes levels , lipid levels in experimental diabetic rats were investigated. Materials and Methods: Thirty two male Wistar-Albino rats (250-300 g) were used as material. The rats were divided into four groups of control (C), diabetes (D), JC oil (J),   and diabetes + JC oil (DJ). D and DJ groups were treated with 45 mg/kg streptozotocin (STZ) (i.p.). JC oil (dissolved in distilled water (0.5% CMC)   was administered as 200 mg/kg/21 days by oral gavage in J and DJ groups. Results: Total cholesterol (TC) and total   triglyceride (TG) levels were observed to have significantly decreased in the J and DJ groups to C and D groups (p≤0.001). There was no difference in TG levels between D group and control group. (p≥0.05). Lipoprotein levels were not statistically significant among all groups (p≥0.05). According to the control group in the diabetes and DJ groups; significantly decreased amylase levels and increased lipase levels (p≤0.001). Paraoxonase activity was have a significant decrease in D group   (p≤0.05). It was identified that the PON levels were significantly increase in the study groups when compared to the diabet group (p≤0.05). Conclusion: The application of JC oil was effective in antihyperglycemia, antihyperlipidemic diabetes. In the other hand the antioxidant PON caused an increase. As a result, it can be effective in reducing the complications that may occur with lipids in diabetes.
Keywords : Diabetes, Juniperus communis oil, Paraoxonase, Lipoproteins, Lipids