THE EFFECT OF VERAPAMIL ADDED TO THE INSUFFLATION SYSTEM USED IN OFF-PUMP CORONARY ARTERY BYPASS SURGERY ON ENDOTHELIAL DAMAGE

Authors : Ahmet Çora, Erdoğan Ibrişim

Pages : 17-23

View : 12 | Download : 10

Publication Date : 2021-04-07

Article Type : Research

Abstract :Coronary artery disease is one of the leading causes of death worldwide. In addition to the medical options in the treatment, surgical intervention options such as percutaneous cardiac interventions and coronary artery bypass graft surgery have also taken place in treatment protocols. Performing surgery using a heart-lung machine in coronary artery bypass surgery has been a significant improvement in terms of anastomosis comfort for surgeons. However, the observation of the complications that may develop due to this machine has led to the birth of off-pump coronary artery bypass surgery, which allows the application of coronary artery bypass surgery without the use of a heart-lung machine in appropriate cases. However, while using this technique, the washing solution, which is a mixture of gas and serum, must be insufflated with pressure to the field for keeping the surgical field blood free. This insufflation itself can cause premature occlusion of anastomoses by causing endothelial damage. In this study, we planned to investigate the protective effects of adding verapamil to the insufflation solution on the endothelium in off-pump coronary bypass
Keywords : Coronary bypass, off-pump coronary bypass graft operation, endothelial damage, verapamil, insufflation solution