The effect of intermittent fasting and water restriction on myocardial ischemia/reperfusion-induced arrhythmia in rats

Authors : Salih Tunç Kaya, Ömer Bozdoğan

Pages : 1484-1489

View : 26 | Download : 8

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :To investigate the effect of intermittent fasting and water restriction on ischemia/reperfusion-induced arrhythmias. Materials and methods: Six minutes of ischemia followed by 6 min of reperfusion was produced by the ligation and then releasing of the left coronary artery. Intermittent fasting and water restriction were applied during 1 month for 12 h/day. The duration, type, and incidence of arrhythmias during reperfusion and the survival rate at the end of reperfusion were determined and compared. Results: The score of arrhythmia that was determined using the type and duration of arrhythmia did not show significant differences among groups. The arrhythmic period was significantly longer in animals subjected to 1 month of intermittent water and food restriction. The risk of ischemic zone was found to be significantly larger in the animals subjected to 1 month of normal feeding after 1 month of food and water restriction. Conclusion: Intermittent fasting and water restriction was not found to be effective in decreasing the arrhythmia that occurred during 6 min of myocardial reperfusion in rats. Since there is no other study compatible with the present study, further research is required on the effect of intermittent fasting and water restriction on ischemia/reperfusion-induced arrhythmia and on the risk of an ischemic zone.
Keywords : Key words: Myocardial ischemia, reperfusion, fasting, water restriction, arrhythmia