Effective synthesis of bicyclodienes via palladium-catalyzed asymmetric allylic alkylation and ruthenium-catalyzed cycloisomerization

Authors : Nizam Havare

Pages : 1445-1462

View : 15 | Download : 6

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :[n.3.0]Bicycles (n = 3-6) can be synthesized using palladium-catalyzed asymmetric allylic alkylation followed by ruthenium-catalyzed cycloisomerization. New types oftriarylphosphino-1,2- diaminooxazoline ligands show the same high levels of enantioselectivity observed with Trost ligand when employed in Pd-catalyzed allylic alkylation reactions. The enyne products of these allylic alkylation reactions were further elaborated using a Ru-catalyzed redox isomerization process, for which a mechanism is proposed.
Keywords : Synthetic method development, asymmetric catalysis, Tsuji-Trost-reaction, palladium-catalyzed asymmetric allylic alkylation, ruthenium-catalyzed cycloisomerization