Synthesis and antitumor activities of 2-(piperidin-4-yl)-thiazole-4-carboxamides analogues of tubulysins

Authors : Xiangfu Peng, Mingsha Shao, Shuchao Ma, Lei Yao

Pages : 676-686

View : 13 | Download : 9

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :}Tubulysins are a family of natural products that exhibit potent antitumor activities, which have attracted much attention from synthetic and medicinal chemists. Previous attempts to aromatize the Tuv part of tubulysin analogues led to a loss in antitumor activity, which suggested that the Ile and Tuv fragments of these analogues were adopting different conformations than the natural products. In this study, a series of 2-(piperidin-4-yl)-thiazole-4-carboxamides have been prepared to investigate whether an intramolecular H-bond between key NH and OH groups is responsible for the conformational control. The antitumor activities of these analogues have been screened using MDA-MB-231-breast, Siha-cervical, MCF7-breast, and PC3-prostate cell lines, with ureas 5m and 5k shown to exhibit moderate antitumor activities (IC$_{50}$ values of 0.2 and 0.6 μM against MCF7 cells, respectively).
Keywords : Tubulysin analogues, antitumor activity, 2-(piperidin-4-yl)-thiazole-4-carboxamides, synthesis