Boric acid as an efficient and green catalyst for the synthesis of 2-amino-4,6-diarylnicotinonitrile under microwave irradiation in solvent-free conditions

Authors : Zahra Hosseinzadeh, Ali Ramazani, Nima Razzaghi-asl, Katarzyna Slepokura, Tadeusz Lis

Pages : 464-474

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Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :Microwave irradiation has been used to improve the one-pot synthesis of substituted 2-amino-4,6-diarylnicoti- nonitrile in the presence of boric acid as an efficient and green catalyst under solvent-free conditions within 48--60 s. All the analogs that have not been reported previously were characterized by their melting points, IR, $^{1}$H NMR, and $^{13}$C NMR spectra. One of the structures was verified by the analysis of a single crystal. The reported synthetic procedure provided remarkable advantages such as short reaction times, excellent yield, facile workup, and the use of a green catalyst.
Keywords : Boric acid, microwave irradiation, solvent-free, green method, 2-amino-4, 6-diarylnicotinonitrile