Design and synthesis of new naphtho[2,1-$b$]pyrano [2,3-$d$]pyrimidinones under classical and microwave conditions

Authors : Maher Cherif, Mariem Debbabi, Sarra Chortani, Anis Romdhane, Hichem Ben Jannet

Pages : 1623-1639

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Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :A fast and efficient method for the synthesis of naphthopyranopyrimidinones derivatives in excellent yields was developed through cyclocondensation reaction between previously prepared pyrimidinic hydrazides and some electrophilic species such as 2,4-pentanedione, 2,5-hexanedione, cyclic anhydrides, and phenylthioisocyanate under microwave irradiation. Compared to the conventional methods applied, it was found that better yields and shorter reaction times were achieved using microwave-assisted synthesis. Structures of all synthesized compounds were established on the basis of spectroscopic methods including $^{1}$H NMR, $^{13}$C NMR, and HRMS-ES.
Keywords : Pyrimidinic hydrazides, cyclocondensation, naphthopyranopyrimidinones derivatives, conventional synthesis, microwave-assisted synthesis