Stereoselective and regioselective synthesis of $N$-substituted methyl 2-((azolyl)methyl)-3-arylacrylates from Baylis-Hillman acetates

Authors : Ayşen Köseceli Özenç, Ilhami Çelik, Şule Kökten

Pages : 323-334

View : 16 | Download : 8

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :$N$-Substituted methyl 2-((azolyl)methyl)-3-arylacrylates were synthesized stereo- and regioselectively with one-pot reaction between Baylis--Hillman acetates and a suitable acylazole in the presence of K$_{2}$CO$_{3}$ as a base catalyst. The targeted $N$-substituted azole acrylates were efficiently obtained in good yields (39%-89%).
Keywords : Imidazole, benzimidazole, benzotriazole, Baylis-Hillman acetates, $N$-substituted azole acrylates