A new series of Cu(II) and Ni(II) complexes of NO bidentate 4-NO2 -benzoylhydrazones: synthesis, characterization, and biological studies

Authors : Hatice Başpinar Küçük, Emel Mataraci Kara, Berna Özbek Çelik

Pages : 939-954

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Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :A series of new nickel(II) and copper(II) hydrazone complexes \textbf{1--14}, containing a bidentate NO-donor hydrazone ligand, derived from 4-nitrobenzoylhydrazide and several aliphatic and aromatic aldehydes were synthesized, and their chemical structures were confirmed by means of FT-IR, UV-Vis, $^{1}$H and $^{13}$C NMR, mass spectral data, conductance measurements, and elemental analyses. The spectral data of the newly synthesized complexes show the formation of a 1:2 [metal:ligand] ratio. The ligands and their complexes were also investigated for their possible in vitro antimicrobial activities against \textit{S. aureus}, \textit{S. epidermidis}, \textit{E. coli}, \textit{K. pneumonia}, \textit{P. aeruginosa}, \textit{P. mirabilis}, \textit{E. faecalis}, and \textit{C. albicans}. Among the fourteen new complexes synthesized, complex Cu(L$_{4})_{2}$ (\textbf{7}) containing a direct aromatic moiety in the ligand (HL$_{7})$ was found to be most active against selected test microorganisms.
Keywords : Hydrazone derivatives, bidentate Schiff base ligand, copper complex, nickel complex, antimicrobial activity