A simple approach to bis-spirocycles and spiroindole derivatives via green methods such as Fischer indolization, ring-closing metathesis, and Suzuki--Miyaura cross-coupling

Authors : Sambasivarao Kotha, Rashid Ali

Pages : 1190-1198

View : 11 | Download : 7

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :We have developed a simple synthetic methodology for bis-spirocycles and spiroindole derivatives starting with a commercially available 6-bromo-2-tetralone. Here, we have used Fischer indolization, ring-closing metathesis, and Suzuki--Miyaura cross-coupling as key steps to assemble a variety of spirocyclic frameworks. The methodology developed here is simple and it may be useful to prepare various spirocycles containing indole moiety.
Keywords : Spirocycles, Fischer indolization, ring-closing metathesis, Suzuki coupling, Grubbs' catalyst