Microwave-assisted synthesis of novel 8-chloro-[1,2,4]triazolo[4,3-a]pyridine derivatives

Authors : Linjiong Zhang, Mingyan Yang, Beizhen Hu, Zhaohui Sun, Xinghai Liu, Jianquan Weng, Chengxia Tan

Pages : 867-873

Doi:10.3906/kim-1408-78

View : 13 | Download : 9

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :A series of novel 1,2,4-triazolo[4,3-$a$]pyridine derivatives were synthesized from 2,3-dichloropyridine and hydrazine hydrate as starting materials by multistep reactions under microwave assistance, and their structures were characterized by $^{1}$H NMR, MS, and elemental analysis. This method provides several advantages such as high yields, facile work-up, and environmental friendliness.
Keywords : 1, 2, 4-Triazolo[4, 3-$a$]pyridine, urea, microwave-assisted synthesis