Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities

Authors : Mohammad Shakhawoat Hossain, Sıdıka Polat Çakirdag, Ayşe Betül Karaduman

Pages : 880-893

Doi:10.3906/kim-1402-6

View : 29 | Download : 8

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl)aluminum reagents to acyl phosphonates in good yields. Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield. Selected propargylic phosphonates were tested for antimicrobial activities. Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.
Keywords : Acyl phosphonates, alkynyl organoaluminum, propargylic alcohols, tris-(phenylethynyl)aluminum, tris-(propynyl)aluminum, antimicrobial activity