Conformational Analysis of Pol-Rfamide II (Glu}1-Trp2-Leu3-Lys4-Gly5-Arg6-Phe7-NH2) Heptapeptide

Authors : Lütfü Demir

Pages : 825-832

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Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :The geometrical structure of the sea anemone and sea pansies neuropeptide Pol-RFamide II Glu1-Trp2-Leu3-Lys4-Gly5-Arg6-Phe7-NH2 was carried out by molecular mechanics (MM). The linkage bonds are characterised by the torsional angles f, y and w and the side groups characterised by the torsional angles c1, c2, c3,... subsequently. The energy-map for each monopeptide of the Pol-RFamide II was drawn in the range of -180° to 180° with increments of 20°. Conformation facilities for monopeptides were decided from these maps. These results were used in the analysis of the dipeptide Glu1-Trp2. Then, the Glu1-Trp2-Leu3 tripeptide was examined by using the calculated results for dipeptide. Conformational analysis of the Glu1-Trp2-Leu3-Lys4 tetrapeptide was performed using the low-energy values of the tripeptide. The geometrical structure of Glu1-Trp2-Leu3-Lys4-Gly5-Arg6-Phe7-NH2 neuropeptide was determined by rotating the tetrapeptide Glu1-Trp2-Leu3-Lys4 and the dipeptide Arg6-Phe7-NH2 about the monopeptide Gly5 due to the minimisation of energy.
Keywords : Turk. J. Chem., 26, (2002), 825-832. Full text: pdf Other articles published in the same issue: Turk. J. Chem., vol.26, iss.6.