Synthesis and Analgesic and Anti-Inflammatory Activity of New Pyridazinones

Authors : Deniz S. Doğruer, M. Fethi Şahin

Pages : 727-738

View : 21 | Download : 10

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :A new series of 2-(6-oxo-3,5-diphenyl-6H-pyridazin-1-yl)- acetamides and 3-[6-oxo-3,5-diphenyl-6H-pyridazin-1-yl)-propanamides were synthesized and evaluated in terms of their analgesic and anti-inflammatory activities. All compounds except for 7g were more potent than aspirin in a p-benzoquinone--induced writhing test at 100 mg/kg dose. Compounds 7b, 7c and 7e had the highest anti-inflammatory activity; compound 7e was the most potent in terms of analgesic and anti-inflammatory activities and had no ulcerogenic side effects.
Keywords : 6-Oxo-3, 5-diphenylpyridazine, synthesis, spectral analysis, analgesic, anti-inflammatory