A Convenient Synthesis of 3,6-Disubstituted1,4-Dihydro-[1,2,4,5]Tetrazines and Preparation of New Acetic Acid Derivatives Containing 5-Oxo-4-Phenylamino-4,5-Dihydro-[1,2,4]Triazole

Authors : Ahmet Demirbaş

Pages : 311-324

View : 16 | Download : 9

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :A series of compounds 8a-e, was synthesized by condensation of compounds 7a-e with ethyl bromoacetate. The treatment of compounds 8a-e with hydrazine hydrate afforded the corresponding hydrazide derivatives (9a-e). Subsequently, compounds 9a-e were converted to alkylidene hydrazides (10a-e). Moreover, upon heating in the presence of carboxylic acids, compounds 9a-e unexpectedly gave 1,4-dihydro-[1,2,4,5]tetrazine derivatives (11a-e).
Keywords : Conformer, geometrical isomer, ethyl bromoacetate, imine bond, 5-oxo-[1, 2, 4]triazole, [1, 2, 4, 5]tetrazine