Synthesis and Antimicrobial Activities of Some New Flavonyl Pro-drug Esters of Ampicillin

Authors : Meltem Ceylan Ünlüsoy, Nurten Altanlar, Rahmiye Ertan

Pages : 187-191

View : 21 | Download : 11

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :A new series of flavonyl pro-drug esters of ampicillin (Va-b) was prepared by condensing the appropriate bromomethyl flavone with ampicillin trihydrate potassium salt. Flavone derivatives and ampicillin both have good antibacterial activity. The synthesized compounds were tested for their antifungal and antibacterial activities in vitro. Both of the compounds were active against Candida krusei and Staphylococcus aureus.
Keywords : Flavone derivatives, Ampicillin, Pro-drug ester, Antimicrobial activities