Organotin (IV) Derivatives of 1-Ethyl-1,4-Dihydro-7- Methyl-4-Oxo-1,8-Naphthyridine-3-Carboxylic Acid (Nalidixic Acid): Synthesis, Structural Elucidation and Biological Activities

Authors : Sajjad Ahmed, Moazzam Hussain Bhatti, Saqib Ali

Pages : 193-202

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Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :Organotin carboxylates of the general formulae R2SnL2 and R3SnL, where R = CH3, n-C4H9, C6H5, CH2C6H5 and L = 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (nalidixic acid), have been prepared. These compounds were characterized by FT-IR, mass and multinuclear NMR (1H, 13C and 119Sn) spectroscopy. The geometry around the tin atom is compared both in solution and in solid state. These compounds were also screened for their antifungal and antibacterial activities.
Keywords : Organotin(IV) complexes, 1-ethyl-1, 4-dihydro-7-methyl-4-oxo-1, 8- naphthyridine-3-carboxylic acid (nalidixic acid), Spectroscopic characterization, Biological Activity