Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation

Authors : Jürgen Krauss, Doris Unterreitmeier, Franz Bracher

Pages : 451-454

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Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :The thiophene analogue of (\pm)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol. The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisation of the triple bond. The resulting thiophene was tested in the MTT assay for its cytotoxic activity against HL 60 cells.
Keywords : Sonogashira reaction, 4-ipomeanol, cytotoxic activity, MTT assay