A New and Convenient Method of Generating Alkyl Isocyanates from Alcohols, Thiols, and Trimethylsilyl Ethers Using a 2,4,6-Trichloro[1,3,5] Triazine/n-Bu4NOCN

Authors : Batool Akhlaghinia, Sima Samiei

Pages : 35-43

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Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :Alkyl isocyanates are prepared in good to excellent yields by treatment of alcohols, thiols, and trimethylsilyl ethers with 2,4,6-trichloro[1,3,5] triazine/n-Bu4NOCN in acetonitrile. This method is highly selective for conversion of 1° alcohols to alkyl isocyanates in the presence of 2° and 3° alcohols, thiols, and trimethylsilyl ethers.
Keywords : 2, 4, 6-Trichloro[1, 3, 5] triazine (TT), alcohol, thiol, trimethylsilyl ether, alkyl isocyanate