Synthesis and Biological Activity of 4-(4-Hydroxybenzylidene)-2- (substituted styryl) oxazol-5-ones and Their o-glucosides

Authors : Vijay Taile, Kishor Hatzade, Pravin Gaidhane And Vishwas Ingle

Pages : 295-305

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Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :The 4-(4-hydroxybenzylidene)-2-methyl oxazol-5-ones 1 were treated with various aldehydes in the presence of acetic acid to form 4-(4-hydroxybenzylidene)-2-(substituted styryl) oxazol-5-ones 2a-i, which were glucosylated using a-acetobromoglucose as a glucosyl donor to afford 4-(4-o-b-d-tetra-o-acetyl-glucoxybenzylidene)-2- (substituted styryl) oxazol-5-ones 3a-i, which were deacetylated using zinc acetate in absolute methanol to form 4-(4-o-b-d-glucoxybenzylidene)- 2-(substituted styryl) oxazol-5-ones 4a-i. The compounds showed good antimicrobial and antifungal activity.
Keywords : Oxazolone, a -acetobromoglucose, decetylation, o-glucosides, antimicrobial and antifungal activity