Synthesis and evaluation of phenytoin derivatives as anticonvulsant agents

Authors : Meenakshi Deodhar, Pravin Sable, Ashok Bhosale, Kapil Juvale

Pages : 367-373

Doi:10.3906/sag-1205-49

View : 15 | Download : 8

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :2,5-Dioxo-4,4-diphenylimidazolidine-1-carboxylic acid (2) was reacted with methyl ester of different amino acids (1a-c) and substituted benzhydrols (3a-b) in pyridine and in the presence of N,N dicyclohexyl carbodiimide (DCC) to yield a series of the title compounds, methyl 2-(2,5-dioxo-4,4-diphenylimidazolidine-1-carboxamido) substituted propanoate (4a-c) and benzhydryl 2,5-dioxo-4,4-diphenyl imidazolidine-1-carboxylate (5a-b). The structures of these compounds were established on the basis of their spectral (IR, 1H-NMR) data. These newly synthesized derivatives of phenytoin were evaluated in terms of anticonvulsant activity.
Keywords : Phenytoin, hydantoin, anticonvulsant activity.