Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

Authors : Deniz S. Doğruer, Şölen Urlu, Tijen Önkol

Pages : 57-65

View : 22 | Download : 10

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 m g/mL) and E. coli (MIC ranging from 4 to 16 m g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 m g/mL.
Keywords : Pyridazine derivatives, antibacterial activity, antifungal activity.