Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles

Authors : Meltem Çetin, Imran Vural, Alptuğ Atila, Yücel Kadioğlu

Pages : 509-516

Doi:10.3906/sag-1208-86

View : 16 | Download : 7

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-co-glycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology of the PLGA microparticles were also determined. A cytotoxicity test was performed by using Glioma RG2 cancer cells to investigate the cytotoxicity of DOX-loaded PLGA microparticles. The DOX-loaded PLGA microparticles had an average diameter of 500 \pm 9 nm. The DOX encapsulation efficiency and drug loading were 22.75% and 0.78%, respectively. DOX-loaded PLGA microparticles displayed a significant cytotoxicity toward the RG2 cells as compared to the unloaded PLGA
Keywords : Turk. J. Chem., 34, (2010), 509-516. Full text: pdf Other articles published in the same issue: Turk. J. Chem., vol.34, iss.4.