Synthesis of some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method, and investigation their anticancer activities

Authors : Ismail Kayagil And Şeref Demirayak

Pages : 13-24

Doi:10.3906/sag-1205-101

View : 14 | Download : 7

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :In this study, some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives were synthesized by reacting 1-(2-aryl-2-oxoethyl)-2-aryloyl-4,5-diarylimidazoles from 2-aryloyl-4,5-diarylimidazole and 2-bromoacetophenone derivatives with ammonium acetate in acetic acid by using the method that was previously developed and repeatedly tested in our studies. Structural elucidation of the compounds was performed by IR, 1H-NMR, and MASS spectroscopic data and elemental analysis results. Anticancer activities of selected compounds were evaluated and the noticeable activity values were reported.
Keywords : Substituted imidazoles, imidazo[1, 2-a]pyrazines, microwave irradiation, anticancer activity