Novel biologically active glycosides from the aerial parts of Cephalaria gazipashensis

Authors : Nazlı Böke Sarikahya And Süheyla Kirmizigül

Pages : 323-334

Doi:10.3906/tar-1208-58

View : 13 | Download : 11

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :Two new triterpene glycosides, 3-O-b-D-glucopyranosyl- (1\to 4)-b-D-xylopyranosyl-(1\to 3)-a-L-rhamnopyranosyl- (1\to 3)-a-L-arabinopyranosyl olean-12-ene 28-O-b -D- glucopyranosyl-(1\to 6)-b-D-glucopyranosyl ester (gazipashoside A, 1) and 3-O-b-D-glucopyranosyl-(1\to 4)-b-D-xylopyranosyl- (1\to 3)-a-L-rhamnopyranosyl-(1\to 2)-a-L-arabinopyranosyl hederagenin 28-O-b -D-glucopyranosyl-(1\to 6)-b-D-glucopyranosyl ester (gazipashoside B, 2), were isolated together with 11 known compounds including 7 triterpene, 1 flavonoid, and 3 iridoidal metabolites from the aerial parts of Cephalaria gazipashensis (Dipsacaceae). The structures of all compounds were elucidated by extensive evaluation of the spectroscopic data (1D- and 2D- NMR, HRESI-MS), as well as chemical examinations. The antimicrobial effects of all pure compounds were tested against gram-positive and gram-negative bacteria. The results indicated that the 2 new triterpene glycosides might be acceptable as antimicrobial active agents.
Keywords : Gazipashoside A, gazipashoside B, Dipsacaceae, Cephalaria gazipashensis, triterpene glycoside, antimicrobial activity