Three-component Passerini-Smiles coupling reaction of aldehydes and isocyanides with tropolone catalyzed by silica nanoparticles

Authors : Abdolhossain Massoudi, Issa Amini, Ali Ramazani And

Pages : 537-544

Doi:10.3906/vet-1302-50

View : 16 | Download : 11

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :The use of Smiles rearrangement in Passerini-type couplings with tropolone allows very straightforward multicomponent formation of a-aryloxy amide derivatives. The 3-component addition of isocyanide to tropolone (2-hydroxy-2,4,6-cycloheptatrien-1-one) and aldehyde in the presence of silica nanoparticles (silica NP, ca. 70 nm) proceeds easily in methanol to form the title compounds in a new Passerini-Smiles-type reaction.
Keywords : Smiles rearrangement, Passerini-type coupling, tropolone, isocyanide, silica nanoparticles, Passerini-Smiles-type reaction