Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold

Authors : Fazel Nasuhi Pur, Karim Akbari Dilmaghani

Pages : 288-296

Doi:10.3906/kim-1307-32

View : 14 | Download : 9

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :Four 6-aminopenicillanic acid moieties were grafted at either rim of calix[4]arene, giving 2 novel generations of penicillin, which were named calixpenam. Antibiotic tests showed that they have amplified activity with respect to the corresponding penams against 3 gram-positive nonpenicillinase-producing strains of Streptococcus.
Keywords : Calixpenam, Calixarene, 6-aminopenicillanic acid, nonpenicillinase, Streptococcus strains