Facile synthesis of 5-bromotropono[c]-fused pyrazoles and isoxazole

Authors : Yang Li, Liangyu Xu, Wentao Gao

Pages : 470-476

Doi:10.3906/fiz-1203-1

View : 15 | Download : 8

Publication Date : 9999-12-31

Article Type : Makaleler

Abstract :A facile synthesis of a series of new 5-bromotropono[c]pyrazole derivatives (3 and 10--15) as well as 5-bromotropono[c]isoxazole (17) is described, involving a condensation reaction of 3-acetyl-5-bromotropolone (1) with hydrazine monohydrate (2), arylhydrazine hydrochlorides (4--9), and hydroxylamine hydrochloride (16), respectively. All the synthesized compounds were obtained in good yields of 56%--77% and their structures were characterized by spectral data and HRMS.
Keywords : Tropono[c]pyrazole, tropono[c]isoxazole, condensation reaction, hydrazine monohydrate, arylhydrazine, hydroxylamine