Transforming growth factor beta 1 TGF-b1 in the pathophysiology of nasal polyp

Authors : Evrim Damcayiri Yeniel, Fatih Turan, Rana Bayram Kablan, Reşit Doğan Köseoğlu

Pages : 93-104

View : 22 | Download : 5

Publication Date : 2018-06-15

Article Type : Research

Abstract :Objectives: This study aims to use immunohistochemistry to compare histopathological findings and transforming growth factor beta 1 TGF-b1 levels in polyp tissue in cases of nasal polyp with histopathological findings and TGF-b1 levels in the nasal mucosa in patients with obstructive nasal deformity. Patients and Methods: The study group consisted of 20 patients. The control group consisted to 20 patients scheduled for nasal surgery due to septum deviation. Edema, mixed infection cell infiltration, eosinophil leukocyte infiltration and squamous metaplasia development were studied from hematoxylin-eosin stained slides containing polyp and conchal mucosa tissue specimens collected from the study and control groups. These were then assessed semi-quantitatively. The presence or absence of TGF-b1 antibody and positive reaction in the mucosal epithelium, submucosal glands, fibroblasts and inflammatory cells were evaluated immunohistochemically. Results: A positive association was determined between eosinophilia and edema on tissue staining with hematoxylin and eosin in cases of nasal polyp, while no edema was observed in any cases in the control group. Comparison of the control and study groups on immunohistochemical TGF-b1 positive reaction staining revealed no significant difference between epithelium, gland and fibroblast staining. Immunohistochemical staining of inflammatory cells was more pronounced in the study group. Conclusion: We conclude that TGF-b1 may play a role together with other mediators, although not alone, in the pathophysiology of nasal polyp.
Keywords : Nasal polyposis, tissue eosinophilia, transforming growth factor beta 1