Thiol-disulphide homeostasis in chronic sinusitis without polyposis

Authors : Kazım Bozdemir, Arife Sezgin, Ahmet Akkoz, Özcan Erel, Mehmet Hakan Korkmaz

Pages : 66-70

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Publication Date : 2018-06-15

Article Type : Research

Abstract :Objectives: Oxidative stress plays a role in the pathogenesis of chronic mucosal inflammation in chronic sinusitis and we aimed to investigate a novel oxidative stress marker, thiol/disulphide homeostasis. Patients and Methods: A total of 60 subjects 30 chronic sinusitis patients and 30 healthy volunteers were included in the study. Thiol/disulphide levels were analyzed with a newly developed method by Erel and Neselioglu. Results: The average native thiol value of the chronic sinusitis group was 475.6 µmol/L and 515.8 µmol/L in the control group. The total thiol was 509.4 and 552.2 µmol/L respectively for the chronic sinusitis and control groups. Chronic sinusitis patients had significantly lower native and thiol value than control group p<.001 and p=.001 . There was no significant difference between chronic sinusitis and control groups with respect to disulphide levels. Conclusion: Serum thiol and disulphide measurements can be used as a novel method for the reflection of inflammation for chronic rhinosinusitis patients.
Keywords : Chronic sinusitis, homesostasis, thiol-disulphide