The Role of Hypericum Perforatum (St. John's Wort Oil) and Olive Oil in the Prevention of Peritoneal Adhesion in a Rat Model: An Animal Study

Authors : Tuğrul Kesicioğlu, Ismail Aydin, Selahattin Vural, Ilkay Çinar, Mehmet Gülmez, Arif Keskin

Pages : 23-30

Doi:10.19127/mbsjohs.1008275

View : 25 | Download : 8

Publication Date : 2022-02-25

Article Type : Research

Abstract :Objective : We aimed to investigate Hypericum Perforatum (St. John's Wort Oil) and pure olive oil with respect to their effect on preventing intra-abdominal adhesions after abdominal surgery. Methods: This was an animal study carried out by the Giresun Faculty of Medicine, Department of General Surgery between August 10, 2020, and September 10, 2020. In the study, intra-abdominal adhesion development was examined macroscopically and microscopically on the 14th day after experimental abdominal surgery in three groups [(i) Control, (ii) olive oil application, (iii) St. John's Wort oil application] each consisting of 7 female Wistar Albino rats. Majuzi classification and Zuhlke's microscopic adhesion classification was used to evaluate adhesions. Results: Macroscopically, fibrous bands were not observed in 1 rat in the control group, 2 rats in olive oil recipients, and 1 rat in St. John's Wort oil recipients. A significant difference between the groups was identified in terms of Zuhlke's microscopic adhesion scores (p = 0.026). Accordingly, the adhesion level was significantly reduced in olive oil recipients compared to controls (p = 0.002). There was no significant difference in terms of adhesion between all groups (p>0.05). The Majuzi adhesion classifications in the control group, olive oil group and St. John's wort groups were also similar (p = 0.308). Conclusion: In rats who underwent abdominal surgery, it was determined that intra-abdominal olive oil application reduced the level of adhesion, while St. John's Wort oil application had no effect on adhesion formation.
Keywords : Abdominal Surgery, Adhesion, St. John, Olive Oil